New Hampshire's Lakes Region is in the center of the state, I-93 passes through the region, and U.S. Route 3 is another road through the Lakes.
From Massachusetts, Connecticut, New York, south and west: Take I-91 north through Massachusetts into Vermont. I-91 follows the New Hampshire/Vermont border, and joins I-89 at near Lebanon, NH Take I-89 south into the Lakes region.
From eastern Massachusetts, Rhode Island, and south and east: Take I-93 north through Massachusetts and into New Hampshire.
From northern New Hampshire, northern Vermont and points north: I-93 is the most direct route, heading southward through the White Mountain area into the region.